As a long-standing employee of the University of Edinburgh I am tremendously excited to be joining the Parasite Immunoepidemiology Group as their lab manager.
Previously I have studied parasite immune evasion strategies, focussing on how parasite excretory-secretory products influence the host immune response. It is widely acknowledged that the production of immune mediating molecules by parasites may be a key means by which they tailor surroundings to facilitate their prolonged survival. I look forward to applying my knowledge gained whist studying H.polygyrus and Brugia malayi to the realm of schistosomiasis infection.
PhD (2014) and MSc (Distinction) from Edinburgh University. Manages laboratory business
Maizels RM, Gomez-Escobar N, Prieto-Lafuente L, Murray J, Aebischer T. Expression of helminth genes in Leishmania : an experimental transfection system to test immunological function. Parasite Immunol 2008;30:195-201.
Murray J, Manoury B, Balic A, Watts C, Maizels RM. Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from C.elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP. Mol Biochem Parasitol 2005;139:197-203.
McSorley HJ, Harcus YM, Murray J, Taylor MD, Maizels RM. Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite, Brugia malayi. . J Immunol 2008; 181: 6456-6466.
McSorley HJ, Grainger JR, Harcus YM, Murray J, Nisbet A, Knox DP, Maizels RM. daf-7-related TGF-β homologues from trichostrongyloid nematodes show contrasting life cycle expression patterns. . Parasitology 2009;in press.
Murray, J, Gregory, WF, Gomez-Escobar, N, Atmadja, A K, Maizels, RM. Expression and immune recognition of Brugia malayi VAL-1, a homologue of vespid venom allergens and Ancylostoma secreted proteins. Mol Biochem Parasitol 2001; 118: 89-96.