Publications

2016

Trainor-Moss S and Mutapi F. Schistosomiasis therapeutics: whats in the pipeline? Exp Rev Clin Pharm 2016; 9: 157-160.

Amanfo SA, Mduluza T, Midzi N, Cavanagh DR and Mutapi F. Seroepidemiology of Plasmodium species infections in Zimbabwean population. Malar J 2016; 15: 267.

2015

Wami WM, Nausch N, Midzi N, Gwisai R, Mduluza T, Woolhouse M and Mutapi F. Identifying and evaluating field indicators of urogenital schistosomiasis-related morbidity in preschool-aged children. PLoS Negl Trop Dis 2015; 9: e0003649.

van der Ree AM and Mutapi F. The helminth parasite proteome at the host-parasite interface - Informing diagnosis and control. Exp Parasitol 2015; 157: 48-58.

Pearson MS, Becker L, Driguez P, Young ND, Gaze S, Mendes T, Li XH, Doolan DL, Midzi N, Mduluza T, McManus DP, Wilson RA, Bethony JM, Nausch N, Mutapi F, Felgner PL and Loukas A. Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates. Front Immunol 2015; 6: 213.

Nausch N, Appleby LJ, Sparks AM, Midzi N, Mduluza T and Mutapi F. Group 2 innate lymphoid cell proportions are diminished in young helminth infected children and restored by curative anti-helminthic treatment. PLoS Negl Trop Dis 2015; 9: e0003627.

Mutapi F. Changing policy and practice in the control of pediatric schistosomiasis. Pediatrics 2015; 135: 536-544.
 

Mutapi F. The gut microbiome in the helminth infected host. Trends Parasitol 2015.

Kay GL, Millard A, Sergeant MJ, Midzi N, Gwisai R, Mduluza T, Ivens A, Nausch N, Mutapi F and Pallen M. Differences in the Faecal Microbiome in Schistosoma haematobium Infected Children vs. Uninfected Children. PLoS Negl Trop Dis 2015; 9: e0003861.

Fukushige M, Mitchell KM, Bourke CD, Woolhouse ME and Mutapi F. A Meta-Analysis of Experimental Studies of Attenuated Schistosoma mansoni Vaccines in the Mouse Model. Front Immunol 2015; 6: 85.

Appleby LJ, Nausch N, Heard F, Erskine L, Bourke CD, Midzi N, Mduluza T, Allen JE and Mutapi F. Down Regulation of the TCR Complex CD3zeta-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation. Front Immunol 2015; 6: 51.

2014

Wami WM, Nausch N, Bauer K, Midzi N, Gwisai R, Simmonds P, Mduluza T, Woolhouse M and Mutapi F. Comparing parasitological vs serological determination of Schistosoma haematobium infection prevalence in preschool and primary school-aged children: implications for control programmes. Parasitology 2014: 1-9.

Nausch N, Dawson EM, Midzi N, Mduluza T, Mutapi F and Doenhoff MJ. Field evaluation of a new antibody-based diagnostic for Schistosoma haematobium and S. mansoni at the point-of-care in northeast Zimbabwe. BMC Infect Dis 2014; 14: 165.

Mitchell KM, Mutapi F, Mduluza T, Midzi N, Savill NJ and Woolhouse ME. Predicted Impact of Mass Drug Administration on the Development of Protective Immunity against Schistosoma haematobium. PLoS Negl Trop Dis 2014; 8: e3059.

Midzi N, Mduluza T, Chimbari MJ, Tshuma C, Charimari L, Mhlanga G, Manangazira P, Munyati SM, Phiri I, Mutambu SL, Midzi SS, Ncube A, Muranzi LP, Rusakaniko S and Mutapi F. Distribution of schistosomiasis and soil transmitted helminthiasis in zimbabwe: towards a national plan of action for control and elimination. PLoS Negl Trop Dis 2014; 8: e3014.

Hoy AM, Lundie RJ, Ivens A, Quintana JF, Nausch N, Forster T, Jones F, Kabatereine NB, Dunne DW, Mutapi F, Macdonald AS and Buck AH. Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection. PLoS Negl Trop Dis 2014; 8: e2701.

Glendinning L, Nausch N, Free A, Taylor DW and Mutapi F. The microbiota and helminths: sharing the same niche in the human host. Parasitology 2014; 141: 1255-1271.

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Trottein F, Midzi N, Mduluza T and Mutapi F. Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment. PLoS Negl Trop Dis 2014; 8: e2846.

Appleby LJ, Nausch N, Erskine L, Bourke CD, Rujeni N, Midzi N, Mduluza T and Mutapi F. CD16 Expression on Monocytes in Healthy Individuals but Not Schistosome-Infected Patients Is Positively Associated with Levels of Parasite-Specific IgG and IgG1. PLoS Negl Trop Dis 2014; 8: e3049.

2013 and before

Rujeni N, Nausch N, Midzi N, Gwisai R, Mduluza T, Taylor DW and Mutapi F. Soluble CD23 Levels are Inversely Associated with Atopy and Parasite-Specific IgE Levels but Not with Polyclonal IgE Levels in People Exposed to Helminth Infection. Int Arch Allergy Immunol 2013; 161: 333-341.

Rujeni N, Nausch N, Midzi N, Cowan GJ, Burchmore R, Cavanagh DR, Taylor DW, Mduluza T and Mutapi F. Immunological consequences of antihelminthic treatment in preschool children exposed to urogenital schistosome infection. J Trop Med 2013; 2013: 283619.

Mutapi F, Billingsley PF and Secor WE. Infection and treatment immunizations for successful parasite vaccines. Trends Parasitol 2013; 29: 135-141.

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Mitchell KM, Midzi N, Mduluza T and Mutapi F. Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis. J Infect Dis 2013; 208: 159-169.

Appleby LJ, Nausch N, Midzi N, Mduluza T, Allen JE and Mutapi F. Sources of heterogeneity in human monocyte subsets. Immunol Lett 2013; 152: 32-41.

Rujeni N, Taylor DW and Mutapi F. Human schistosome infection and allergic sensitisation. J Parasitol Res 2012; 2012: 154743.

Rujeni N, Nausch N, Midzi N, Mduluza T, Taylor DW and Mutapi F. Schistosoma haematobium infection levels determine the effect of praziquantel treatment on anti-schistosome and anti-mite antibodies. Parasite Immunol 2012.

Rujeni N, Nausch N, Bourke CD, Midzi N, Mduluza T, Taylor DW and Mutapi F. Atopy Is Inversely Related to Schistosome Infection Intensity: A Comparative Study in Zimbabwean Villages with Distinct Levels of Schistosoma haematobium Infection. Int Arch Allergy Immunol 2012; 158: 288-298.

Reilly L, Nausch N, Midzi N, Mduluza T and Mutapi F. Association between Micronutrients (Vitamin A, D, Iron) and Schistosome-Specific Cytokine Responses in Zimbabweans Exposed to Schistosoma haematobium. J Parasitol Res 2012; 2012: 128628.

Nausch N, Louis D, Lantz O, Peguillet I, Trottein F, Chen IY, Appleby LJ, Bourke CD, Midzi N, Mduluza T and Mutapi F. Age-related patterns in human myeloid dendritic cell populations in people exposed to Schistosoma haematobium infection. PLoS Negl Trop Dis 2012; 6: e1824.

Nausch N, Bourke CD, Appleby LJ, Rujeni N, Lantz O, Trottein F, Midzi N, Mduluza T and Mutapi F. Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium. Sci Rep 2012; 2: 472.

Mutapi F. Advances in parasite control in Africa: from basic science to translation. J Parasitol Res 2012; 2012: 158039.

Mutapi F. Helminth parasite proteomics: from experimental models to human infections. Parasitology 2012: 1-10.

Mitchell KM, Mutapi F, Savill NJ and Woolhouse ME. Protective immunity to Schistosoma haematobium infection is primarily an anti-fecundity response stimulated by the death of adult worms. Proc Natl Acad Sci U S A 2012; 109: 13347-13352.

Harvala H, McIntyre CL, Imai N, Clasper L, Djoko CF, LeBreton M, Vermeulen M, Saville A, Mutapi F, Tamoufe U, Kiyang J, Biblia TG, Midzi N, Mduluza T, Pepin J, Njouom R, Smura T, Fair JN, Wolfe ND, Roivainen M and Simmonds P. High seroprevalence of enterovirus infections in apes and old world monkeys. Emerg Infect Dis 2012; 18: 283-286.

Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F and Zamoyska R. Chronic Infection Drives Expression of the Inhibitory Receptor CD200R, and Its Ligand CD200, by Mouse and Human CD4 T Cells. PLoS One 2012; 7: e35466.

Bourke CD, Mutapi F, Nausch N, Photiou DM, Poulsen LK, Kristensen B, Arnved J, Ronborg S, Roepstorff A, Thamsborg S, Kapel C, Melbye M and Bager P. Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response. Clin Exp Allergy 2012; 42: 1582-1595.

Appleby LJ, Nausch N, Bourke CD, Rujeni N, Midzi N, Mduluza T, Allen JE and Mutapi F Chitinase 3-like 1 protein levels are elevated in Schistosoma haematobium infected children. PLoS Negl Trop Dis 2012; 6: e1898.

Stothard JR, Sousa-Figueiredo JC, Betson M, Green HK, Seto EY, Garba A, Sacko M, Mutapi F, Vaz Nery S, Amin MA, Mutumba-Nakalembe M, Navaratnam A, Fenwick A, Kabatereine NB, Gabrielli AF and Montresor A. Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children. Parasitology 2011; 138: 1593-1606.

Nausch N, Midzi N, Mduluza T, Maizels RM and Mutapi F. Regulatory and Activated T Cells in Human Schistosoma haematobium Infections. PLoS One 2011; 6: e16860.

Mutapi F, Rujeni N, Bourke C, Mitchell K, Appleby L, Nausch N, Midzi N and Mduluza T. Schistosoma haematobium treatment in 1-5 year old children: safety and efficacy of the antihelminthic drug praziquantel. PLoS Negl Trop Dis 2011; 5: e1143.

Mutapi F, Imai N, Nausch N, Bourke CD, Rujeni N, Mitchell KM, Midzi N, Woolhouse ME, Maizels RM and Mduluza T. Schistosome infection intensity is inversely related to auto-reactive antibody levels. PLoS One 2011; 6: e19149.

Mutapi F, Bourke C, Harcus Y, Midzi N, Mduluza T, Turner CM, Burchmore R and Maizels RM. Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4. Parasite Immunol 2011; 33: 181-192.

Mutapi F. Improving diagnosis of urogenital schistosome infection. Expert Rev Anti Infect Ther 2011; 9: 863-865.

Mitchell KM, Mutapi F, Savill NJ and Woolhouse ME. Explaining observed infection and antibody age-profiles in populations with urogenital schistosomiasis. PLoS Comput Biol 2011; 7: e1002237.

Midzi N, Mtapuri-Zinyowera S, Sangweme D, Paul NH, Makware G, Mapingure MP, Brouwer KC, Mudzori J, Hlerema G, Chadukura V, Mutapi F, Kumar N and Mduluza T. Efficacy of integrated school based de-worming and prompt malaria treatment on helminths -Plasmodium falciparum co-infections: A 33 months follow up study. BMC Int Health Hum Rights 2011; 11: 9.

Midzi N, Mtapuri-Zinyowera S, Mapingure MP, Paul NH, Sangweme D, Hlerema G, Mutsaka MJ, Tongogara F, Makware G, Chadukura V, Brouwer KC, Mutapi F, Kumar N and Mduluza T. Knowledge attitudes and practices of grade three primary schoolchildren in relation to schistosomiasis, soil transmitted helminthiasis and malaria in Zimbabwe. BMC Infect Dis 2011; 11: 169.

Imai N, Rujeni N, Nausch N, Bourke CD, Appleby LJ, Cowan G, Gwisai R, Midzi N, Cavanagh D, Mduluza T, Taylor D and Mutapi F. Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria. Parasitology 2011; 138: 1519-1533.

Higon M, Cowan G, Nausch N, Cavanagh D, Oleaga A, Toledo R, Stothard JR, Antunez O, Marcilla A, Burchmore R and Mutapi F. Screening trematodes for novel intervention targets: a proteomic and immunological comparison of Schistosoma haematobium, Schistosoma bovis and Echinostoma caproni. Parasitology 2011; 138: 1607-1619.

Bourke CD, Maizels RM and Mutapi F. Acquired immune heterogeneity and its sources in human helminth infection. Parasitology 2011; 138: 139-159.

Milner T, Reilly L, Nausch N, Midzi N, Mduluza T, Maizels R and Mutapi F. Circulating cytokine levels and antibody responses to human Schistosoma haematobium: IL-5 and IL-10 levels depend upon age and infection status. Parasite Immunol 2010; 32: 710-721.

Midzi N, Mtapuri-Zinyowera S, Mapingure MP, Sangweme D, Chirehwa MT, Brouwer KC, Mudzori J, Hlerema G, Mutapi F, Kumar N and Mduluza T. Consequences of polyparasitism on anaemia among primary school children in Zimbabwe. Acta Trop 2010; 115: 103-111.

Mduluza T, Mutapi F, Ruwona T, Kaluka D, Midzi N and Ndhlovu PD. Similar cellular responses after treatment with either praziquantel or oxamniquine in Schistosoma mansoni infection. Malawi Med J 2009; 21: 176-182.

Reilly LJ, Magkrioti C, Cavanagh DR, Mduluza T and Mutapi F. Effect of treating Schistosoma haematobium infection on Plasmodium falciparum-specific antibody responses. BMC Infect Dis 2008; 8: 158.

Mutapi F, Burchmore R, Mduluza T, Midzi N, Turner CM and Maizels RM. Age-related and infection intensity-related shifts in antibody recognition of defined protein antigens in a schistosome-exposed population. J Infect Dis 2008; 198: 167-175.

Mitchell KM, Mutapi F and Woolhouse ME. The predicted impact of immunosuppression upon population age-intensity profiles for schistosomiasis. Parasite Immunol 2008: 462-470.

Midzi N, Sangweme D, Zinyowera S, Mapingure MP, Brouwer KC, Munatsi A, Mutapi F, Mudzori J, Kumar N, Woelk G and Mduluza T. The burden of polyparasitism among primary schoolchildren in rural and farming areas in Zimbabwe. Trans R Soc Trop Med Hyg 2008; 102: 1039-1045.

Midzi N, Sangweme D, Zinyowera S, Mapingure MP, Brouwer KC, Kumar N, Mutapi F, Woelk G and Mduluza T. Efficacy and side effects of praziquantel treatment against Schistosoma haematobium infection among primary school children in Zimbabwe. Trans R Soc Trop Med Hyg 2008; 102: 759-766.

Mutapi F, Winborn G, Midzi N, Taylor M, Mduluza T and Maizels RM. Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting profiles for IFN-gamma, IL-4, IL-5 and IL-10 with age. BMC Infect Dis 2007; 7: 139.

Mutapi F, Roussilhon C, Mduluza T and Druilhe P. Anti-malaria humoral responses in children exposed to Plasmodium falciparum and Schistosoma haematobium. Mem Inst Oswaldo Cruz 2007; 102: 405-409.

Doleckova K, Kasny M, Mikes L, Mutapi F, Stack C, Mountford AP and Horak P. Peptidases of Trichobilharzia regenti (Schistosomatidae) and its molluscan host Radix peregra S. Lat. (Lymnaeidae): construction and screening of cDNA library from intramolluscan stages of the parasite. Folia Parasitol (Praha) 2007; 54: 94-98.

Zinyowera S, Muchaneta-Kubara CE, Mutapi F, Midzi N, Ndlovu PD and Mduluza T. Changes in the humoral immune responses after chemotherapy in single and co-infected individuals with Schisosoma haematobium and Plasmodium falciparum. Cent Afr J Med 2006; 52: 104-111.

Mutapi F, Mduluza T, Gomez-Escobar N, Gregory WF, Fernandez C, Midzi N and Maizels RM. Immuno-epidemiology of human Schistosoma haematobium infection: preferential IgG3 antibody responsiveness to a recombinant antigen dependent on age and parasite burden. BMC Infect Dis 2006; 6: 96.

Mutapi F, Mduluza T and Roddam AW. Cluster analysis of schistosome-specific antibody responses partitions the population into distinct epidemiological groups. Immunol Lett 2005; 96: 231-240.

Mutapi F, Burchmore R, Foucher A, Harcus Y, Nicoll G, Midzi N, Turner C and Maizels R. Praziquantel treatment of people exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens. J Infect Dis 2005; 192: 1108-1118.

Mutapi F, Hagan P, Woolhouse ME, Mduluza T and Ndhlovu PD. Chemotherapy-induced, age-related changes in antischistosome antibody responses. Parasite Immunol 2003; 25: 87-97.

Mutapi F, Gryseels B and Roddam A. On the calculation of intestinal schistosome infection intensity. Acta Trop 2003; 87: 225-233.

Mduluza T, Ndhlovu PD, Midzi N, Scott JT, Mutapi F, Mary C, Couissinier-Paris P, Turner CM, Chandiwana SK, Woolhouse ME, Dessein AJ and Hagan P. Contrasting cellular responses in Schistosoma haematobium infected and exposed individuals from areas of high and low transmission in Zimbabwe. Immunol Lett 2003; 88: 249-256.

Mutapi F and Roddam A. p values for pathogens: statistical inference from infectious-disease data. Lancet Infect Dis 2002; 2: 219-230.

Mutapi F, Mduluza T and Ndhlovu PD. The effect of treatment on the age-antibody relationship in children infected with Schistosoma mansoni and Schistosoma haematobium. Mem Inst Oswaldo Cruz 2002; 97 Suppl 1: 173-180.

Scott JT, Turner CM, Mutapi F, Woolhouse ME, Ndhlovu PD and Hagan P. Cytokine responses to mitogen and Schistosoma haematobium antigens are different in children with distinct infection histories. Parasite Immunol 2001; 23: 519-526.

Mutapi F. Heterogeneities in anti-schistosome humoral responses following chemotherapy. Trends in Parasitol 2001; 17: 518-524.

Woolhouse ME, Mutapi F, Ndhlovu PD, Chandiwana SK and Hagan P. Exposure, infection and immune responses to Schistosoma haematobium in young children. Parasitology 2000; 120 ( Pt 1): 37-44.

Scott JT, Turner C, Mutapi F, Woolhouse ME, Chandiwana SK, Mduluza T, Ndhlovu PD and Hagan P. Dissociation of interleukin-4 and interleukin-5 production following treatment for Schistosoma haematobium infection in humans. Parasite Immunol 2000; 22: 341-348.

Mutapi F, Ndhlovu PD, Hagan P and Woolhouse ME. Anti-schistosome antibody responses in children coinfected with malaria. Parasite Immunol 2000; 22: 207-209.

Chan MS, Mutapi F, Woolhouse ME and Isham VS. Stochastic simulation and the detection of immunity to schistosome infections. Parasitology 2000; 120 ( Pt 2): 161-169.

Mutapi F, Ndhlovu PD, Hagan P and Woolhouse ME. A comparison of re-infection rates with Schistosoma haematobium following chemotherapy in areas with high and low levels of infection. Parasite Immunol 1999; 21: 253-259.

Mutapi F, Ndhlovu PD, Hagan P and Woolhouse ME. Changes in specific anti-egg antibody levels following treatment with praziquantel for Schistosoma haematobium infection in children. Parasite Immunol 1998; 20: 595-600.

Mutapi F, Ndhlovu PD, Hagan P, Spicer JT, Mduluza T, Turner CM, Chandiwana SK and Woolhouse ME. Chemotherapy accelerates the development of acquired immune responses to Schistosoma haematobium infection. J Infect Dis 1998; 178: 289-293.

Mutapi F, Ndhlovu PD, Hagan P and Woolhouse ME. A comparison of humoral responses to Schistosoma haematobium in areas with low and high levels of infection. Parasite Immunol 1997; 19: 255-263.

Mutapi F, Hagan P, Ndhlovu P and Woolhouse MEJ. Comparison of humoral responses to Schistosoma haematobium in areas  with high and low levels of infection. Parasite Immunology 1997; 19: 255-263.